Cancer Research

Princeton, NJ — Just as it’s hard to understand a conversation without knowing its context, it can be difficult for biologists to grasp the significance of gene expression without knowing a cell’s environment. To solve that problem, researchers at Princeton Engineering have developed a method to elucidate a cell’s surroundings so that biologists can make […]

Memphis, TN — Rhabdomyosarcoma is a type of soft tissue cancer. Scientists at St. Jude Children’s Research Hospital studied the population of cells that persists after therapy, causing rhabdomyosarcoma recurrence. They found that these cells mirror an early developmental state that responds to EGFR inhibitors. The work presents a strategy for targeting the whole tumour […]

La Jolla, CA — Mammals can’t typically regenerate organs as efficiently as other vertebrates, such as fish and lizards. Now, Salk scientists have found a way to partially reset liver cells to more youthful states—allowing them to heal damaged tissue at a faster rate than previously observed. The results, published in Cell Reports on April […]

Niigata, Japan — The research group of Professor Kamimura in Niigata University have established a novel pancreatic carcinogenesis model in wild-type rats utilizing the pancreas-targeted selective hydrodynamic gene delivery method developed by their research group. “The gene human pancreatic cancer-related gene transfer of the KRASG12D efficiently developed the pancreatic cancer”, says Prof. Kamimura. KRASG12D-induced pancreatic […]

Ann Arbor, MI — In a small but multi-institutional study, an artificial intelligence-based system improved providers’ assessments of whether patients with bladder cancer had complete response to chemotherapy before a radical cystectomy (bladder removal surgery). Yet the researchers caution that AI isn’t a replacement for human expertise and that their tool shouldn’t be used as […]

La Jolla, CA — Every day, your pancreas produces about one cup of digestive juices, a mixture of molecules that can break down the food you eat. But if these powerful molecules become activated before they make their way to the gut, they can damage the pancreas itself—digesting the very cells that created them, leading […]

Singapore — In the fight against cancer, the development of efficacious drugs is only half the battle; equally important is how drugs may be delivered efficiently and safely to the diseased sites in the body. The challenge of drug delivery is especially pertinent for RNA therapeutics which target an important immuno-modulatory receptor, RIG-I. When activated […]

Pittsburgh, PA — Fighting cancer and chronic disease is tiring work for the immune system. When T cells are engaged in this kind of lengthy battle, they can become exhausted, or unable to function properly. One immunotherapy that revitalizes these cells by blocking an immune checkpoint protein called LAG3 was recently approved by federal regulators. […]

Philadelphia, PA – Researchers have found that treating prostate cancer cells with novel cyclin-dependent kinase 19 (CDK19) and homologous cyclin-dependent kinase 8 (CDK8) inhibitors reduces their potential to migrate into and invade surrounding structures. These molecules may be used as single or combination therapy for patients with advanced disease to prevent and treat metastatic spread. […]

La Jolla, CA — Researchers at University of California San Diego School of Medicine and Moores Cancer Center at UC San Diego Health, with collaborators at La Jolla Institute for Immunology and elsewhere, have further elucidated how ovarian cancer tumours defy immunotherapy, identifying new molecular targets that might boost immune response. The findings will publish […]

New Orleans — Dr. Susana Garcia-Recio, a research associate in the lab of Dr. Charles M. Perou, at UNC Lineberger Comprehensive Cancer Center, will present findings that identified molecular features responsible for the development and progression of metastatic breast cancer at the 2022 American Association for Cancer Research annual meeting. (Presentation: Abstract  LB176/4, Tuesday, April […]

Houston, TX — Houston Methodist researchers have identified the genetic and molecular fingerprints of different cancer and immune cells in glioblastoma, the deadliest and most common type of brain cancer in adults. Their in-depth molecular analysis of over 200,000 single cells revealed a protein, called S100A4, that could be a potential therapeutic target for restoring […]