Mindzilla – Disease Processes

Disease Processes

Chaperone Protein Imbalance Promotes Toxic Tau Buildup in Ageing Brain

April 21, 2021
Mindzilla

Tampa, FL — Chaperone protein imbalance can play a significant role in initiating toxic accumulation of tau in the ageing brain – an early step in the development of Alzheimer’s disease...

How Tangled Proteins Kill Brain Cells, Promote Alzheimer’s, CTE

April 19, 2021
Mindzilla

Boulder, CO — Look deep inside the brain of someone with Alzheimer’s disease, most forms of dementia or the concussion-related syndrome known as chronic traumatic encephalopathy (CTE) and you’ll...

Researchers Discover New Way to Monitor & Prevent Nerve Cell Deterioration After TBI

April 14, 2021
Mindzilla

Cleveland, OH — Violent blows or jolts to the head can cause traumatic brain injury (TBI), and there are currently about five million people in the U.S. living with some form of chronic impairment...

Chemical Modification of RNA could Play Key Role in Polycystic Kidney Disease

April 14, 2021
Mindzilla

Dallas, TX — A chemical modification of RNA that can be influenced by diet appears to play a key role in polycystic kidney disease, an inherited disorder that is the fourth leading cause of kidney...

PLD3 Gene Contributes to Risk of Alzheimer’s Disease

April 12, 2021
Mindzilla

Nashville, TN — A rare and controversial mutation in the phospholipase D3 (PLD3) protein – previously linked to Alzheimer’s disease – interferes with PLD3’s vital recycling...

Artificial Intelligence could ‘Crack the Language of Cancer and Alzheimer’s’

April 12, 2021
Mindzilla

Cambridge, UK — Powerful algorithms used by Netflix, Amazon and Facebook can ‘predict’ the biological language of cancer and neurodegenerative diseases like Alzheimer’s, scientists...

Mouse Models of Neurodevelopmental Disorders Display Metabolic Dysfunction

April 7, 2021
Mindzilla

Ottawa, ON — Mouse models of neurodevelopmental disorders possess unique, sex-specific metabolic dysfunctions, according to a new study in eNeuro. Understanding the unique metabolic effects of each...

New Blueprint of Brain Connections Reveals Extensive Reach of Central Regulator

April 7, 2021
Mindzilla

La Jolla, CA — Thousands of our daily activities, from making coffee to taking a walk to saying hello to a neighbour, are made possible through an ancient collection of brain structures tucked away...

First Non-Invasive Biomarker to Track and Verify Efficacy of Senolytic Drugs

April 7, 2021
Mindzilla

Novato, CA — Buck Institute researchers have discovered and are developing a novel, non-invasive biomarker test that can be used to measure and track performance of senolytics: a class of drugs that...

New Approach for the Development of a Drug Treatment for Obesity and the Resulting Diseases

April 6, 2021
Mindzilla

Munich, Germany — The protein Asc-1 regulates whether fat-burning beige or fat-storing white adipocytes are formed, which can have an impact on the development of metabolic diseases. This is shown...

Scientists Find Genetic Link to Clogged Arteries

April 6, 2021
Mindzilla

St. Louis, MO — High cholesterol is the most commonly understood cause of atherosclerosis, a hardening of the arteries that raises the risk of heart attack and stroke. But now, scientists at Washington...

Stopping the Sickness: Protein may be Key to Blocking a Nauseating Bacterium

April 1, 2021
Mindzilla

Pullman, WA — Washington State University researchers have discovered a protein that could be key to blocking the most common bacterial cause of human food poisoning in the United States. Chances...

Bespoke Neuroblastoma Therapy Weaponizes Cell Metabolism

April 1, 2021
Mindzilla

Richmond, VA — Preclinical research from VCU Massey Cancer Center published recently in the Proceedings of the National Academy of Sciences shows that the combination of two existing drugs can exploit...

Lab Model Offers Hope for Macular Degeneration Patients

March 30, 2021
Mindzilla

Rochester, NY — Age-related macular degeneration (AMD), which leads to a loss of central vision, is the most frequent cause of blindness in adults 50 years of age or older, affecting an estimated 196...

Incurable Leigh Syndrome: German Scientists Create First Human Model for Rare Disease

March 29, 2021
Mindzilla

Düsseldorf, Germany — Leigh syndrome is the most severe mitochondrial disease in children. It causes severe muscle weakness, movement defects, and intellectual disabilities. It usually leads to death...

New Study Provides Detailed View of How Hepatitis B Virus Establishes Chronic Infection

March 15, 2021
Mindzilla

Princeton, NJ — Researchers at Princeton have determined how five cellular proteins contribute to an essential step in the life cycle of hepatitis B virus (HBV). The article describing these findings...

Study Shows Simple Blood Test could Detect Liver Injury Earlier

March 11, 2021
Mindzilla

Richardson, TX — University of Texas at Dallas chemist Dr. Jie Zheng has spent much of his career investigating gold nanoparticles for their potential impact in the field of nanomedicine. In new research,...

Huntington’s Disease Driven by Slowed Protein-Building Machinery in Cells

March 8, 2021
Mindzilla

Jupiter, FL — In 1993, scientists discovered that a single mutated gene, HTT, caused Huntington’s disease, raising high hopes for a quick cure. Yet today, there’s still no approved treatment. One...

Induced Pluripotent Stem Cells Reveal Causes of Disease

March 5, 2021
Mindzilla

Heidelberg, Germany — Induced pluripotent stem cells (iPSC) are suitable for discovering the genes that underly complex and also rare genetic diseases. Scientists from the German Cancer Research Center...

Protein Controlling Magnesium Identified as Therapeutic Target for Non-Alcoholic Fatty Liver Disease

March 5, 2021
Mindzilla

New York, NY — An international team of researchers has identified the CNNM4 protein as a key regulator of magnesium in the liver and potential therapeutic target for non-alcoholic fatty liver disease,...

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