Mindzilla – Drug Development

Drug Development

Discovery of a Potential New Therapy for Inflammatory Arthritis

October 21, 2021
Mindzilla

Toronto, Canada — In a paper published Oct. 20 in the journal Science Translational Medicine, researchers at the Schroeder Arthritis Institute, part of University Health Network (UHN) in Toronto, have...

Research Breakthrough Could Mean Better Treatment for Patients With Most Deadly Form of Brain Tumour

October 21, 2021
Mindzilla

London, UK — Scientists studying the most common and aggressive type of brain tumour in adults have discovered a new way of analysing diseased and healthy cells from the same patient. Crucially,...

A Cousin of Viagra Reduces Obesity by Stimulating Cells to Burn Fat, Study Suggests

October 7, 2021
Mindzilla

Baltimore, MD — Researchers at Johns Hopkins Medicine have found that a drug first developed to treat Alzheimer’s disease, schizophrenia and sickle cell disease reduces obesity and fatty liver in mice...

Novel Small Molecule Potently Attenuates Neuroinflammation in Brain and Glial Cells

September 30, 2021
Mindzilla

Birmingham, AL — Neuroinflammation can worsen outcomes in stroke, traumatic brain injury or spinal cord injury, as well as accelerate neurodegenerative diseases like ALS, Parkinson’s or Alzheimer’s....

An Integrated Genomic Database for Traditional Medicines – the GPGD

September 9, 2021
Mindzilla

Beijing, China — Traditional medicines have been globally used to treat various diseases for thousands of years, and critically, still play important roles in modern-day healthcare. During the coronavirus...

Drug Delivery Capsule could Replace Injections for Protein Drugs

September 3, 2021
Mindzilla

Cambridge, MA — In recent years, scientists have developed monoclonal antibodies — proteins that mimic the body’s own immune defenses — that can combat a variety of diseases, including some cancers...

Cancer Therapy Breakthrough In Vitro Using Self-Assembled Drugs

August 23, 2021
Mindzilla

Huddersfield, UK — One of the most challenging aspects of cancer treatment is the huge variety of different tumours that can occur with each one potentially requiring a different solution because unfortunately,...

New Drug Combo Shows Early Potential for Treating Pancreatic Cancer

August 10, 2021
Mindzilla

Cambridge, MA — Pancreatic cancer, which affects about 60,000 Americans every year, is one of the deadliest forms of cancer. After diagnosis, fewer than 10 percent of patients survive for five years. While...

Chemists Propose a One-Step Synthesis of Substances for Medicine

July 19, 2021
Mindzilla

Moscow, Russia — The RUDN University chemists have discovered a reaction for the synthesis of acetimidamides, heterocyclic compounds with biological activity that can be used for the synthesis of hormones,...

‘Unexciting’ an Anxious Brain: Novel Drug Reduces Anxiety-like Behaviour in Mice

June 30, 2021
Mindzilla

Tokyo, Japan — Anxiety, commonly termed as a feeling of fear, dread, and restlessness, is a perfectly normal reaction to stressful situations. However, a state of heightened anxiety, which is the reality...

New Drug-Formulation Method may Lead to Smaller Pills

June 8, 2021
Mindzilla

Cambridge, MA — About 60 percent of drugs on the market have hydrophobic molecules as their active ingredients. These drugs, which are not soluble in water, can be difficult to formulate into tablets...

Drug Development Platform could Provide Flexible, Rapid and Targeted Antimicrobials

April 21, 2021
Mindzilla

Boulder, CO — When disease outbreaks happen, response time in developing and distributing treatments is crucial to saving lives. Unfortunately, developing custom drugs as countermeasures is often a...

Designing Better Antibody Drugs with Artificial Intelligence

April 16, 2021
Mindzilla

Zürich, Switzerland — Antibodies are not only produced by our immune cells to fight viruses and other pathogens in the body. For a few decades now, medicine has also been using antibodies produced...

Anti-Inflammatory Drug Protects Against Lethal Inflammation from COVID-19 in Animal Models

April 1, 2021
Mindzilla

New York, NY — Mount Sinai researchers have found that a widely available and inexpensive drug targeting inflammatory genes has reduced morbidity and mortality in mice infected with SARS-CoV-2, the...

Chemists Achieve Breakthrough in Production of 3D Molecular Structures

March 26, 2021
Mindzilla

Münster, Germany — A major goal of organic and medicinal chemistry in recent decades has been the rapid synthesis of three-dimensional molecules for the development of new drugs. These drug candidates...

Focusing on the Unhealthy Brain to Speed Drug Discovery

March 23, 2021
Mindzilla

Houston, TX — Though 40 million concussions are recorded annually, no effective treatment exists for them or for many other brain-related illnesses. In collaboration with Dragan Maric of the National...

Faster Drug Discovery Through Machine Learning

March 16, 2021
Mindzilla

Cambridge, MA — Drugs can only work if they stick to their target proteins in the body. Assessing that stickiness is a key hurdle in the drug discovery and screening process. New research combining...

Common Bacteria Modified to Make Designer Sugar-Based Drug

March 3, 2021
Mindzilla

Troy, NY — Envisioning an animal-free drug supply, scientists have — for the first time — reprogrammed a common bacterium to make a designer polysaccharide molecule used in pharmaceuticals...

Research Team Develops Dual-Targeting Drug for EBV-Related Cancers

March 3, 2021
Mindzilla

Hong Kong, China — A Hong Kong Baptist University-led (HKBU) research team has developed a novel drug which has the potential to become a next-generation treatment for cancers associated with Epstein-Barr...

New Substance to Suppress Neuroinflammation

March 1, 2021
Mindzilla

Moscow, Russia — Biologists from RUDN University confirmed that a well-known spasmolytic drug called hymecromone can suppress the inflammatory response in astrocytes, important glial cells of the central...

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