Mindzilla – Drug Development

Drug Development

Drug Aprotinin Inhibits Entry of SARS-CoV2 in Host Cells

November 24, 2020
Mindzilla

Frankfurt, Germany — The surface of the SARS-CoV-2 virus is studded with spike proteins. The virus needs these in order to dock onto proteins (ACE2 receptors) on the surface of the host cell. Before...

Insights in the Search for New Antibiotics

November 20, 2020
Mindzilla

Norman, OK — A collaborative research team from the University of Oklahoma, the Memorial Sloan Kettering Cancer Center and Merck & Co. published an opinion article in the journal, Nature Chemical...

Comprehensive Safety Testing of COVID-19 Vaccines Based on Experience with Prior Vaccines

November 19, 2020
Mindzilla

Washington, DC — “The urgent need for COVID-19 vaccines must be balanced with the imperative of ensuring safety and public confidence in vaccines by following the established clinical safety...

New Drug for HCM Reduces Heart Mass

November 17, 2020
Mindzilla

Ann Arbor, MI — For the first time, a medication has impacted heart muscle thickness and function for patients with the most common inherited heart condition, rather than simply addressing their symptoms. “This...

Two Anti-Inflammatory Compounds Shown to be Capable of Accelerating Recovery from COVID-19

November 16, 2020
Mindzilla

São Paulo, Brazil — Two independent clinical studies – one by researchers at the Center for Cell-Based Therapy (CTC) in Ribeirão Preto, state of São Paulo (Brazil), on the monoclonal antibody eculizumab,...

Study Reveals Strategy to Create COVID-19 Drugs to Inhibit Virus’s Entry and Replication

November 6, 2020
Mindzilla

Tampa FL — SARS-CoV-2, the respiratory virus that causes COVID-19, attacks the body in multiple steps. Gaining entry into cells deep within the lungs and hijacking the human host cell’s machinery...

Viral ‘Molecular Scissor’ is Next COVID-19 Drug Target

October 20, 2020
Mindzilla

San Antonio, TX — American and Polish scientists, reporting Oct. 16 in the journal Science Advances, laid out a novel rationale for COVID-19 drug design – blocking a molecular “scissor”...

Novel Antiviral Strategy for Treatment of COVID-19

October 19, 2020
Mindzilla

Hong Kong, China — A research team led by Professor Hongzhe SUN, Norman & Cecilia Yip Professor in Bioinorganic Chemistry, Department of Chemistry, Faculty of Science, and Professor Kwok Yung YUEN,...

Scientists Develop New Precise Therapeutic Leukaemia Vaccine

October 13, 2020
Mindzilla

Beijing, China — Exploration of new leukaemia antigens and construction of appropriate delivery systems using FDA-approved material are important strategies for developing leukaemia vaccines for clinic...

Anti-Convulsant Drug can Modify DNA Conformation and Interact with Chromosome Proteins

September 29, 2020
Mindzilla

São Paulo, Brazil — Results of recent studies involving valproic acid, used for decades as an anti-convulsant drug, show that it can interact with the conformation of DNA and regulate gene expression. These...

Attacking Tumours from the Inside

September 7, 2020
Mindzilla

Dallas, TX — A new technology that allows researchers to peer inside malignant tumours shows that two experimental drugs can normalize aberrant blood vessels, oxygenation, and other aspects of the...

New Syringe Technology could Enable Injection of Highly Concentrated Biologic Drugs

August 25, 2020
Mindzilla

Cambridge, MA — MIT researchers have developed a simple, low-cost technology to administer powerful drug formulations that are too viscous to be injected using conventional medical syringes. The...

Developing Precise Medicines for Triple Negative Breast Cancer

August 25, 2020
Mindzilla

Toronto, Canada — Taking advantage of a cancer cell’s altered metabolism that drives its runaway growth, Princess Margaret researchers are zeroing in on these molecular changes to help them develop...

PARP Inhibitor Becomes New Treatment Option for Some Men with Advanced Prostate Cancer

August 17, 2020
Mindzilla

Chicago, IL — Results from an international clinical trial found that men with advanced prostate cancer who have mutated BRCA1/BRCA2 genes can be treated successfully with a targeted therapy known...

Machine Learning Makes Drug Repurposing for Psychiatric Disorders more Effective

August 4, 2020
Mindzilla

São Paulo, Brazil — Artificial intelligence can increase the effectiveness of drug repositioning or repurposing research, according to a study published in Translational Psychiatry. In the study, which...

Tinkering with Roundworm Proteins Offers Hope for Anti-Ageing Drugs

August 3, 2020
Mindzilla

Daejeon, South Korea — KAIST researchers have been able to dial up and down creatures’ lifespans by altering the activity of proteins found in roundworm cells that tell them to convert sugar...

Researchers Identify MicroRNA that Shows Promise for Hair Regrowth

July 28, 2020
Mindzilla

Raleigh, NC — Researchers from North Carolina State University have identified a microRNA (miRNA) that could promote hair regeneration. This miRNA – miR-218-5p – plays an important role...

New Nano Drug Candidate Kills Aggressive Breast Cancer Cells

July 21, 2020
Mindzilla

Fayetteville, AR — Researchers at the University of Arkansas have developed a new nano drug candidate that kills triple negative breast cancer cells. Triple negative breast cancer is one of the...

New Technology Promises to Revolutionize Nanomedicine

July 20, 2020
Mindzilla

Dolgoprudny, Russia — Researchers from the Moscow Institute of Physics and Technology and their colleagues from Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry and Prokhorov General Physics...

Chemical Tailor-Made Suit for Alzheimer’s Drugs

July 20, 2020
Mindzilla

Göttingen, Germany — With over 1.2 million people affected in Germany alone and over 50 million people worldwide, Alzheimer’s disease, also referred to simply as Alzheimer’s, is one of...

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