Mindzilla – Drug Development

Drug Development

Compounds Halt SARS-CoV-2 Replication by Targeting Key Viral Enzyme

July 7, 2020
Mindzilla

Tampa, FL — As the death toll from the COVID-19 pandemic mounts, scientists worldwide continue their push to develop effective treatments and a vaccine for the highly contagious respiratory virus. University...

New Technique in Which Drugs Make Bacteria Glow could Help Fight Antibiotic Resistance

July 6, 2020
Mindzilla

Exeter, UK — New technique in which drugs make bacteria glow could help fight antibiotic resistance A new technique could help reduce antibiotic prescribing by predicting which drugs could be effective...

Cell ‘Membrane on a Chip’ Could Speed up Screening of Drug Candidates for COVID-19

July 3, 2020
Mindzilla

Cambridge, UK — Researchers have developed a human cell ‘membrane on a chip’ that allows continuous monitoring of how drugs and infectious agents interact with our cells, and may soon be...

Designing Anew: Radical COVID-19 Drug Development Approach Shows Promise

July 1, 2020
Mindzilla

Austin, TX — Nearly every drug that is, or has ever been, used was derived from nature — harnessing compounds created by organisms over eons to fight diseases. But decades ago, biochemists postulated...

Existing Drugs can Prevent SARS-CoV-2 from Hijacking Cells

June 30, 2020
Mindzilla

Cambridge, UK — An international team of researchers has analysed how SARS-CoV-2, the virus that causes COVID-19, hijacks the proteins in its target cells. The research, published in the journal Cell,...

Newly Designed Ligands for a Catalytic Reaction to Synthesize Drugs and Useful Compounds

June 30, 2020
Mindzilla

Gwangju, South Korea — Currently, various therapeutic compounds in the market, such as proteins, enzymes, and amino acids, are “chiral compounds”–molecules with two structures that...

Scientists Propose Strategy for Site-Selective Chiral Drug Synthesis in Living Systems

June 29, 2020
Mindzilla

Beijing, China — Enantioselectivity plays an important role in the pharmacological and toxicological processes of chiral drugs. In chiral drug synthesis that uses bioorthogonal chemistry within...

New Compounds from Starfish of Kuril Basin Show Efficacy Against Cancer Cells.

June 29, 2020
Mindzilla

Primorsky Krai, Russia — Russian scientists from Far Eastern Federal University (FEFU), G. B. Elyakov Pacific Institute of Bioorganic Chemistry (PIBOC FEB RAS), and A.V. Zhirmunsky National Scientific...

Virtually Screening Antiviral Compounds Against SARS-CoV-2 Structure may Speed Up Drug and Vaccine D

June 25, 2020
Mindzilla

Washington, DC — Virtually screening antiviral compounds to model their interactions with the SARS-CoV-2 virus may enable scientists to more easily identify antiviral drugs that work against the virus...

How Cancer Drugs Find Their Targets could Lead to New Toolset for Drug Development

June 18, 2020
Mindzilla

Cambridge, MA — In the watery inside of a cell, complex processes take place in tiny functional compartments called organelles. Energy-producing mitochondria are organelles, as is the frilly golgi...

Three New Studies Identify Neutralizing Antibodies Against SARS-CoV-2

June 16, 2020
Mindzilla

Washington, DC — A trio of papers describes several newly discovered human antibodies that target the SARS-CoV-2 virus, isolated from survivors of SARS-CoV-2 and SARS-CoV infection. Several of these...

COVID-19 Mouse Model will Speed Search for Drugs, Vaccines

June 11, 2020
Mindzilla

St. Louis, MO — The global effort to quickly develop drugs and vaccines for COVID-19 has been hampered by limited numbers of laboratory mice that are susceptible to infection with SARS-CoV-2, the virus...

Immunodominant Epitopes Identified for Designing Peptide-Based Vaccine Against SARS-CoV-2

June 10, 2020
Mindzilla

Ramat Gan, Israel — There are currently no licensed vaccines available for COVID-19. While several antiviral drugs have been tested, none has proved to be completely effective against the disease....

Microneedling Therapeutic Stem Cells Into Damaged Tissues

June 10, 2020
Mindzilla

Los Angeles, CA — Mesenchymal stem cells (MSCs) are multipotent in that they naturally replenish the cell types that build our bone, cartilage and adipose tissues. However, their much broader regenerative...

Drug Researcher Develops ‘Fat Burning’ Molecule

June 9, 2020
Mindzilla

Blacksburg, VA — Obesity affects more than 40 percent of adults in the United States and 13 percent of the global population. With obesity comes a variety of other interconnected diseases including...

Deadly Superbug could Get a Vigorous Foe in Repurposed Antibiotic

June 9, 2020
Mindzilla

Los Angeles, CA — USC researchers have discovered that an old antibiotic may be a powerful new tool against a deadly superbug, thanks to an innovative screening method that better mimics conditions...

Near-Atomic ‘Blueprint’ Reveals Inner Workings of Drug Target for Cancer, Other Diseases

June 3, 2020
Mindzilla

Grand Rapids, MI — Van Andel Institute scientists have for the first time described the near-atomic level structure of a molecular pathway that plays critical roles in human development, blood pressure...

COVID-19 Drug Development Could Benefit From Approach Used Against Flu, Says Study

June 3, 2020
Mindzilla

Austin, TX — A new study from researchers at The University of Texas at Austin has found that some antivirals are useful for more than helping sick people get better — they also can prevent thousands...

Modified Parkinson’s Drug Shows Potential in Treating Nonalcoholic Fatty Liver Disease

May 29, 2020
Mindzilla

Gwangju, South Korea — Nonalcoholic fatty liver disease (NAFLD) is a condition characterized by excessive fat accumulation in the liver. It can cause serious complications, including nonalcoholic steatohepatitis,...

Taking Inventory of Which Drugs the World is Using to Treat COVID-19

May 28, 2020
Mindzilla

Philadelphia, PA — With doctors and researchers around the world searching for effective treatments for COVID-19, many drugs approved to treat other diseases are being used in hopes that they’ll...

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