Mindzilla – Pediatrics

Pediatrics

Blood Test Detects Childhood Tumours Based on Their Epigenetic Profiles

June 2, 2021
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Vienna, Austria — A new study exploits the characteristic epigenetic signatures of childhood tumours to detect, classify and monitor the disease. The scientists analyzed short fragments of tumour DNA...

Immunity Boost in the Gut

May 28, 2021
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Adelaide, Australia — Varying immune response to vaccinations could be countered with microbiota-targeted interventions helping infants, older people and others to take full advantage of the benefits...

Targeting Abnormal Cell Metabolism Shows Promise for Treating Paediatric Brain Tumours

May 21, 2021
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Baltimore, MD — Two experimental drug approaches that target vulnerabilities in cancer cell metabolism may extend survival and enhance the effectiveness of standard chemotherapies for a highly aggressive...

Genetic tools help identify a cellular culprit for type 1 diabetes

May 20, 2021
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La Jolla, CA — By mapping its genetic underpinnings, researchers at University of California San Diego School of Medicine have identified a predictive causal role for specific cell types in type 1...

Research Reveals Potential Treatment to Prevent Obesity-Driven Liver Damage

May 18, 2021
Mindzilla

Cincinnati, OH — One of the especially dangerous health risks of being extremely overweight occurs when an obese person begins to accumulate fat in their liver. This condition–non-alcoholic...

Rare Genetic Disease Caused by Mutations in Protein that Controls RNA Metabolism

May 10, 2021
Mindzilla

Pittsburgh, PA — In a paper published today in Nature Communications, an international group of collaborators led by researchers at UPMC Children’s Hospital of Pittsburgh have identified a genetic...

‘Information Theory’ Recruited to Help Scientists Find Cancer Genes

April 21, 2021
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Baltimore, MD — Using a widely known field of mathematics designed mainly to study how digital and other forms of information are measured, stored and shared, scientists at Johns Hopkins Medicine and...

Autism Gene Study Finds Widespread Impact to Brain’s Growth Signalling Network

April 9, 2021
Mindzilla

Jupiter, FL — Damage to the autism-associated gene Dyrk1a, sets off a cascade of problems in developing mouse brains, resulting in abnormal growth-factor signaling, undergrowth of neurons, smaller-than-average...

Researchers Find Ribosome Assembly Essential for Stem Cell Regeneration

March 15, 2021
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Philadelphia, PA — Researchers at Children’s Hospital of Philadelphia (CHOP) have identified genes responsible for hematopoietic stem cell (HSC) regeneration via the assembly of the ribosome,...

Light and Genetic Probes Untangle Dynamics of Brain Blood Flow

February 18, 2021
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Seattle, WA — While the human brain has over 400 miles of total vasculature, little is known about the tiny capillaries that make up much of this intricate labyrinth of blood vessels critical for delivering...

Creating a Safe CAR T-Cell Therapy to Fight Solid Tumours in Children

January 22, 2021
Mindzilla

Los Angeles, CA — Chimeric Antigen Receptor T-cell therapy–CAR T–has revolutionized leukemia treatment. Unfortunately, the therapy has not been effective for treating solid tumours including...

Using Play to “school” Children’s Emotions

December 15, 2020
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Geneva, Switzerland — Being socially and emotionally competent from an early age is likely to help children win acceptance by their peers, build better relationships with teachers, and facilitate academic...

Rap Music Increasingly Mixes in Mental Health Metaphors

December 8, 2020
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Chapel Hill, NC — The most popular rap songs in the United States are increasingly referencing depression and suicide and mixing in metaphors about mental health struggles, according to a study from...

Study Pinpoints Target for Managing Inflammation, Promoting Tissue Repair

November 17, 2020
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Cincinnati, OH — Managing the activity of the BCAP protein could help the body repair intestinal tissue from damage caused by inflammation, according to a new study led by experts at Cincinnati Children’s. The...

New Insight into a Placental Gene Pathway and Its Association with Vitamin D

November 10, 2020
Mindzilla

Charleston, SC — According to the World Health Organization, preeclampsia affects between 2% to 8% of pregnancies. It can cause serious, sometimes fatal, complications in the mother and child. Among...

Cord Blood DNA can Hold Clues for Early ASD Diagnosis and Intervention

October 26, 2020
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Davis, CA — A new study led by UC Davis MIND Institute researchers found a distinct DNA methylation signature in the cord blood of newborns who were eventually diagnosed with autism spectrum disorder...

The Road to Uncovering a Novel Mechanism for Disposing of Misfolded Proteins

October 22, 2020
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Houston, TX — About 30 years ago, Dr. Richard Sifers set out on a journey to discover why people with a rare condition known as alpha1-antitrypsin (AAT) deficiency present with high variation in the...

Rare Congenital Heart Defect Rescued by Protease Inhibition

October 19, 2020
Mindzilla

Greenwood, SC — A research team at the Greenwood Genetic Center (GGC) has successfully used small molecules to restore normal heart and valve development in an animal model for Mucolipidosis II (ML...

Single Gene Disorders not so Simple After All

October 13, 2020
Mindzilla

Chicago, IL — Traditionally, geneticists divide disorders into “simple,” where a single gene mutation causes disease, or complex, where mutations in many genes contribute modest amounts....

Kawasaki Disease is Not a Homogenous Disease Nor are Its Triggers

October 1, 2020
Mindzilla

La Jolla, CA — Researchers at University of California San Diego report that while Kawasaki disease (KD) occurs in clusters, the traits, and thus the triggers of the inflammatory disease vary among...

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