Science

Philadelphia, PA – Researchers have found that treating prostate cancer cells with novel cyclin-dependent kinase 19 (CDK19) and homologous cyclin-dependent kinase 8 (CDK8) inhibitors reduces their potential to migrate into and invade surrounding structures. These molecules may be used as single or combination therapy for patients with advanced disease to prevent and treat metastatic spread. […]

Jena, Germany — A chip-based infection model developed by researchers in Jena, Germany, enables live microscopic observation of damage to lung tissue caused by the invasive fungal infection aspergillosis. The team developed algorithms to track the spread of fungal hyphae as well as the response of immune cells. The development is based on a “lung-on-chip” […]

Los Angeles, CA — UCLA scientists and colleagues have created a first-of-its-kind roadmap that traces each step in the development of blood stem cells in the human embryo, providing scientists with a blueprint for producing fully functional blood stem cells in the lab. The research, published today (Apr.13) in the journal Nature, could help expand treatment options for […]

La Jolla, CA — How do the lungs develop after taking their first breaths outside the womb? What cellular events and changes early in life give rise to lung malfunction and disease? To help answer these questions, scientists have constructed the first single-cell atlas of postnatal lung development in humans and mice. The research could […]

La Jolla, CA — Researchers at University of California San Diego School of Medicine and Moores Cancer Center at UC San Diego Health, with collaborators at La Jolla Institute for Immunology and elsewhere, have further elucidated how ovarian cancer tumours defy immunotherapy, identifying new molecular targets that might boost immune response. The findings will publish […]

New Orleans — Dr. Susana Garcia-Recio, a research associate in the lab of Dr. Charles M. Perou, at UNC Lineberger Comprehensive Cancer Center, will present findings that identified molecular features responsible for the development and progression of metastatic breast cancer at the 2022 American Association for Cancer Research annual meeting. (Presentation: Abstract  LB176/4, Tuesday, April […]

Irvine, CA — A new study, led by researchers from the University of California, Irvine, identifies a reason for why older adults are significantly more susceptible to infectious diseases than younger people, a critical societal issue most recently exemplified by the COVID-19 pandemic. Study results also pave the way for new potential therapeutic targets to […]

Hiroshima, Japan — Milling rice to separate the grain from the husks produces about 100 million tons of rice husk waste globally each year. Scientists searching for a scalable method to fabricate quantum dots have developed a way to recycle rice husks to create the first silicon quantum dot (QD) LED light. Their new method […]

Baton Rouge, LA — A recently discovered chemical compound helped elderly mice with obesity lose fat and weight, add muscle and strength, reduce age-related inflammation and increase physical activity, a new study shows. The study, published in the Journal of Cachexia, Sarcopenia and Muscle, provides the first evidence that BAM15, a mitochondrial uncoupler, prevents sarcopenic obesity, […]

Chicago, IL — Using a protein nanoparticle they designed, scientists at the University of Illinois Chicago have identified two distinct subtypes of neutrophils and found that one of the subtypes can be used as a drug target for inflammatory diseases.  Neutrophils are a type of white blood cell that help fight infection, clear dead cell […]

Houston, TX — Houston Methodist researchers have identified the genetic and molecular fingerprints of different cancer and immune cells in glioblastoma, the deadliest and most common type of brain cancer in adults. Their in-depth molecular analysis of over 200,000 single cells revealed a protein, called S100A4, that could be a potential therapeutic target for restoring […]

Madison, WI — A new biodegradable gel improves the immune system’s ability to keep cancer at bay after tumours are surgically removed. The gel, tested in mice, releases drugs and special antibodies that simultaneously deplete immune-blocking cells called macrophages from the surgical site and activate T cells so they can attack cancer. University of Wisconsin–Madison […]