Proteomics

Singapore — In the fight against cancer, the development of efficacious drugs is only half the battle; equally important is how drugs may be delivered efficiently and safely to the diseased sites in the body. The challenge of drug delivery is especially pertinent for RNA therapeutics which target an important immuno-modulatory receptor, RIG-I. When activated […]

Pittsburgh, PA — Fighting cancer and chronic disease is tiring work for the immune system. When T cells are engaged in this kind of lengthy battle, they can become exhausted, or unable to function properly. One immunotherapy that revitalizes these cells by blocking an immune checkpoint protein called LAG3 was recently approved by federal regulators. […]

La Jolla, CA — Researchers at University of California San Diego School of Medicine and Moores Cancer Center at UC San Diego Health, with collaborators at La Jolla Institute for Immunology and elsewhere, have further elucidated how ovarian cancer tumours defy immunotherapy, identifying new molecular targets that might boost immune response. The findings will publish […]

Houston, TX — Houston Methodist researchers have identified the genetic and molecular fingerprints of different cancer and immune cells in glioblastoma, the deadliest and most common type of brain cancer in adults. Their in-depth molecular analysis of over 200,000 single cells revealed a protein, called S100A4, that could be a potential therapeutic target for restoring […]

Bochum, Germany — It is well known that co-infections with hepatitis viruses do exist. “However, the co-infection of hepatitis C and E has not yet been systematically researched,” says Thomas Burkard. “Even though the possibility always looms that a simultaneous infection with two viruses could perhaps be particularly dangerous.” A single protein suppresses infection In […]

Salt Lake City, UT — A new study led by researchers at University of Utah Health details a novel mechanism that infectious bacteria use to quickly adjust to environmental stress. The discovery could help explain why certain types of common infections—such as urinary tract and bloodstream infections like sepsis—are hard to get rid of.  The mechanism, […]

Los Angeles, CA — As scientists work toward finding a cure for Parkinson’s disease, one line of research that has emerged focuses on mitochondria, the structures within cells that make energy. The health of those structures is maintained through a quality control system that balances two opposite processes: fission — one mitochondrion splitting in two […]

Champaign, IL — Researchers studying epileptic seizures of the temporal lobe – the most common type of epilepsy – discovered a compound that reduces seizures in the hippocampus, a brain region where many such seizures originate. The compound, known as TC-2153, lessened the severity of seizures in mice. The scientists report their findings in the […]

Huddersfield, UK — Huddersfield researchers were among the first to demonstrate how the induction of brain inflammation accounts for neurological damage in COVID19 patients and now, their findings have been published in the peer-reviewed medical journal Molecular Neurobiology. The study, led by the University of Huddersfield’s Dr. Mayo Olajide, describes how the spike protein used […]

Tokyo, Japan — Researchers at the University of Tokyo have for the first time been able to create an RNA molecule that replicates, diversifies and develops complexity, following Darwinian evolution. This has provided the first empirical evidence that simple biological molecules can lead to the emergence of complex lifelike systems.   Life has many big questions, […]

Singapore — Scientists from Nanyang Technological University, Singapore (NTU Singapore) have developed a novel method of delivering drugs into human cells using large biological molecules, by first encasing them in a protein-based microdroplet. This discovery promises to be faster, safer, more effective, and better suited for gene therapy, cancer treatment, and vaccine delivery, including mRNA-based […]

Charleston, SC — Alzheimer’s disease is an enormous problem that, with an ageing population, will only get bigger. More than 6 million Americans are living with Alzheimer’s disease, and 1 in 3 seniors will die of it, according to the Alzheimer’s Association. By 2050, the cost of Alzheimer’s disease, currently estimated at $355 billion, will rise […]