2 min readScientists Discover Retroviral Link to Chronic Fatigue Syndrome
Bethesda, MD – Researchers from the Whittemore Peterson Institute (WPI), the National Cancer Institute (NCI) and the Cleveland Clinic have reported a discovery of a potential retroviral link to chronic fatigue syndrome, known as CFS, a debilitating disease that affects millions of people in the United States. The findings were published online on the October 8, 2009, issue of Science.
“We now have evidence that a retrovirus named XMRV is frequently present in the blood of patients with CFS. This discovery could be a major step in the discovery of vital treatment options for millions of patients,” said Dr. Judy Mikovits, director of research for WPI and leader of the team that discovered this association. However, researchers cautioned that this finding only shows that there is an association between XMRV and CFS, but does not prove that XMRV causes CFS.
The scientists provide a new hypothesis for a retrovirus link with CFS. The virus, XMRV, was first identified by Dr. Robert H. Silverman, professor in the Department of Cancer Biology at the Cleveland Clinic Lerner Research Institute, in men who had a specific immune system defect that reduced their ability to fight viral infections.
Commonality of an immune system defect in patients with CFS and prostate cancer led researchers to look for the virus in their blood samples. In this study, WPI scientists identified XMRV in the blood of 68 of 101 (67 percent) CFS patients. In contrast, they found that eight of 218 healthy people (3.7 percent) contained XMRV DNA. The research team not only found that blood cells contained XMRV but also expressed XMRV proteins at high levels and produced infectious viral particles. A clinically validated test to detect XMRV antibodies in patients’ plasma is currently under development, according to the press report.
“The discovery of XMRV in two major diseases, prostate cancer and now chronic fatigue syndrome, is very exciting. If cause-and-effect is established, there would be a new opportunity for prevention and treatment of these diseases,” said Silverman, a co-author on the CFS paper.
These results were also supported by the observation of retrovirus particles in patient samples when examined using transmission electron microscopy. The data demonstrate the first direct isolation of infectious XMRV from humans.
“These compelling data allow the development of a hypothesis concerning a cause of this complex and misunderstood disease, since retroviruses are a known cause of neurodegenerative diseases and cancer in man,” said Dr. Francis Ruscetti, Laboratory of Experimental Immunology, NCI.
Retroviruses like XMRV have also been shown to activate a number of other latent viruses. This could explain why so many different viruses, such as Epstein-Barr virus, which was causally linked to Burkitt’s and other lymphomas in the 1970s, have been associated with CFS. It is important to note that retroviruses, like XMRV, are not airborne.
“The scientific evidence that a retrovirus is implicated in CFS opens a new world of possibilities for so many people,” said Annette Whittemore, founder and president of WPI and mother of a CFS patient. “Scientists can now begin the important work of translating this discovery into medical care for individuals with XMRV related diseases.”
Dr. Dan Peterson, medical director of WPI added, “Patients with CFS deal with a myriad of health issues as their quality of life declines. I’m excited about the possibility of providing patients, who are positive for XMRV, a definitive diagnosis, and hopefully very soon, a range of effective treatments options.”