1 min readNew Findings Link Oestrogen and T Cell Immune Response to Autoimmune Inflammation
Turku, Finland — Women are more prone to the development of autoimmune diseases. The female hormone oestrogen is likely to affect the immune system.
A team of scientists from Turku Center for Biotechnology and University of Georgia reported new findings related to the involvement of oestrogen hormone receptor in autoimmune diseases.
The incidence of autoimmune diseases such as MS, RA, and SLE is higher in women than in men. The oestrogen hormone secreted in women may contribute to the pathogenesis of these diseases.
A research team led by Docent Zhi Chen from Turku Center for Biotechnology of the University of Turku has collaborated with researchers from the University of Georgia, United States to address the long-standing issue of hormonal effect on autoimmune diseases.
Oestrogen hormone shows its action on cells mostly through oestrogen receptor alpha (ERα). Researchers from Turku generated mice with ERα protein specifically deleted in T cells.
“The eureka moment of our research is that in a mouse model of human inflammatory bowel disease, transfer of naive T helper cells from ERα deficient mice did not succumb to colitis, unlike transfer from their counterparts,” Docent Zhi Chen tells.
“Furthermore, using cutting-edge technique RNA sequencing approach combined with in vitro and in vivo experiments, we discovered that ERα regulates multiple aspects of T cell function, including T cell activation, proliferation and survival, Chen adds.
Regulatory T cells are group of T cells that help in preventing autoimmune diseases. The researchers found that ERα influences the function and differentiation of regulatory T cells.
Article adapted from a University of Turku news release.
Publication: Oestrogen receptor α contributes to T cell–mediated autoimmune inflammation by promoting T cell activation and proliferation. Mohammad, I et al. Science Signaling (April 17, 2018): Click here to view.