2 min readStudy Finds Flu Shot Halves Risk of Heart Attack or Stroke in People with History of Heart Attack

Toronto, ON, Canada – The flu vaccine may not only ward off serious complications from influenza, it may also reduce the risk of heart attack or stroke by more than 50 per cent among those who have had a heart attack.

And the vaccine’s ability to protect the heart may be even greater among those who receive a more potent vaccine.

The findings are the result of new research led by Dr. Jacob Udell, a clinician-scientist at the University of Toronto and a cardiologist at Women’s College Hospital.

“Our study provides solid evidence that the flu shot helps prevent heart disease in vulnerable patients —with the best protection in the highest risk patients,” Dr. Udell said. “These findings are extraordinary given the potential for this vaccine to serve as yearly preventative therapy for patients with heart disease, the leading cause of death among men and women in North America.”

Published Oct. 22 in the Journal of the American Medical Association, the study reviewed six clinical trials on heart health in people who received the flu vaccine. The studies included more than 6,700 patients with a history of heart disease. The researchers found people who received the flu shot:

  • Had a 36 percent lower risk of a major cardiac event (heart attack, stroke, heart failure, or death from cardiac–related causes) one year later
  • Had a 55 percent lower risk of a major cardiac event if they had a recent heart attack
  • Were less likely to die from cardiac-related and other causes, and
  • Were less likely to have a major cardiac event with a more potent vaccine compared with the standard seasonal vaccine

Udell carried out this research in collaboration with Dr. Michael Farkouh, senior co-author of the study, associate professor of the Department of Medicine at U of T and chair of the Peter Munk Centre of Excellence in Multinational Clinical Trials at the Peter Munk Cardiac Centre at the University Health Network.

“If the flu vaccine can reduce the risk of cardiac events, these shots could have considerable impact on cardiac health,” said Udell. However, Udell and Farkouh caution that a large prospective clinical trial is necessary to confirm the effectiveness and safety of the influenza vaccine as a therapy that will reduce the risk of heart attack or stroke in people with heart disease. The researchers are now organizing this type of clinical trial to follow heart disease patients for up to 12 months after receiving the flu shot.

“These findings are all the ammunition we need to move forward,” said Farkouh, who is also director of the Heart and Stroke Richard Lewar Centre at the University of Toronto. “We’ll build on this research with a definitive, international trial to conclusively determine whether the flu shot prevents heart attack.”

If proven to be a safe and simple prevention method, the impact could be significant for people with or at risk of heart disease and stroke.

“Hundreds of thousands of people die each year from cardiac causes in North America,” Udell said. “While preventative care involves lifestyle changes and taking your pills, now, we may also be able to tell patients by getting your flu shot, it might save your life – what a simple and significant way to reduce deaths and the burden on our healthcare system.”

Publication: Association Between Influenza Vaccination and Cardiovascular Outcomes in High-Risk Patients. Jacob A. Udell, Rami Zawi, Deepak L. Bhatt, Maryam Keshtkar-Jahromi, Fiona Gaughran, Arintaya Phrommintikul, Andrzej Ciszewski, Hossein Vakili, Elaine B. Hoffman, Michael E. Farkouh, Christopher P. Cannon. JAMA. (October 2013): http://jama.jamanetwork.com/article.aspx?articleid=1758749

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