2 min readResearchers Find Promising Results with Local Hyperthermia of Tumour

Lebanon, NH – A combination of iron-oxide nanoparticles and an alternating magnetic field, which together generate heat, have activated an immune system response to tumours in mice according to an accepted manuscript by Dartmouth-Hitchcock Norris Cotton Center researchers in the journal Nanomedicine: Nanotechnology, Biology and Medicine released online on February 24, 2014.

“The study demonstrates that controlled heating of one tumour can stimulate an immune response that attacks another tumor that has not had the heat treatment,” said Dr. Steve Fiering, Norris Cotton Cancer Center researcher and professor of Microbiology and Immunology, and of Genetics at the Geisel School of Medicine at Dartmouth. “This is one way to try to train the immune system to attack metastatic tumours that may not be recognized yet.”

Researchers injected iron-oxide nanoparticles into the tumour and then activated those agents with magnetic energy. Researchers were able to activate antigen-presenting dendritic cells in the body’s immune system. Dendritic cells somewhat serve as “quarterbacks” for body’s immune system by calling for quick coordinated protection against an attack. The “quarterback” cells show the defensive “killer” T cells (CD8+ cells) who to attack and these cells then directly attack tumour cells and send out an alert system to engage other cells in the fight against the cancer. The combination of these two aspects of the immune response reduce risk of recurrence and discourage spreading or metastasis of the cancer. This result was observed in sites close to the primary tumour as well as distant sites. In the experiments conducted as part of this study the primary tumour resisted regrowth for one month following overheating.

The magnetic hyperthermia system used was developed by co-author Dr. P. Jack Hoopes, DVM, co-director of Norris Cotton Cancer Center’s Nanotechnology Working Group. “It enables very precise control of the heating to keep the temperature at a uniform 43 degrees C for as long as desired,” said Fiering. “This precise control was the key to optimal immune stimulation.”

The experiment included mouse colon and, melanoma cancers. Tumours responded to the heat by growing more slowly or disappearing completely. A higher temperature was better at eliminating primary tumours that were heat treated, but did not activate the immune system as well to find and attack metastatic tumours. Treatment of larger primary tumours generated a stronger immune response.

In the effort to develop better cancer treatments, the challenge is to find ways to cure metastatic disease. “The use of the immune system through cancer immunotherapy is a very exciting field currently and promises to contribute significantly to elimination of metastatic tumors,” said Fiering. “The approach demonstrated is a good new option to be combined with other immunotherapy strategies for cancer therapy.”

Standard cancer care involves surgery, but surgeons have few tools to guarantee the removal of every cancer cell, especially when there is unrecognized metastases in other anatomic locations. An approach like local hyperthermia one day might be used to kick start the immune system to ward off any cancer cells not removed by surgery to increase the chances of treatment success.

Publication: Activation of multiple signaling pathways during the differentiation of mesenchymal stem cells cultured in silicon nanowire microenvironment. Dandan Liu, Changqing Yi, Chi-Chun Fong, Qinghui Jin, Zuankai Wang, Wai-Kin Yu, Dong Sun, Jianlong Zhao, Mengsu Yang. Nanomedicine: Nanotechnology, Biology and Medicine (February 24, 2014): http://www.nanomedjournal.com/article/S1549-9634

Nanomedicine

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