1 min readScientists Report Dual-Action Compound Kills Cancer Cells, Stops Them from Spreading
Washington, DC – Scientists are reporting development and successful lab tests on the first potential drug to pack a lethal one-two punch against melanoma skin cancer cells.
Hit number one destroys cells in the main tumour, and the second hit blocks the spread of the cancer to other sites in the body, according to their report in the journal ACS Chemical Biology.
Nathan Luedtke and colleagues explain that the spread of melanoma and other forms of cancer beyond the original location ― a process called metastasis ― makes cancer such a serious disease. Photodynamic therapy (PDT), which involves administering a drug that kills cancer cells when exposed to light, already is available. But PDT works only on the main tumour and has other drawbacks. Luedtke’s team set out to find an improved approach to PDT.
The scientists describe successful tests in laboratory mice of one compound they synthesized that not only killed melanoma cells, but also stopped them from metastasizing by blocking a key signal inside the tumour cells. The compound “provides the first example of a preclinical candidate possessing both of these properties,” the scientists state.
Publication: Photodynamic Agents with Anti-metastatic Activities. Balayeshwanth R. Vummidi, Faiza Noreen, Jawad Alzeer, Karin Moelling, and Nathan W. Luedtke. ACS Chemical Biology (Article ASAP): http://pubs.acs.org/stoken/presspac/presspac/abs/10.1021/cb400008t