2 min readResearch Reveals How Muscles Talk to Brain to Regulate Feeding Behaviour

Memphis, TN — The brain determines when it is time to feed – but how does it know? Findings from St. Jude Children’s Research Hospital provide new understanding of how the brain orchestrates this process. Skeletal muscle, like other tissues, communicates with the brain to convey information about nutritional status. The researchers showed that manipulating this mechanism influences food seeking and feeding in fruit flies. This work was published online today in Genes & Development

Tissues like adipose, intestine and liver signal to the brain through hormones that regulate feeding behaviour. Skeletal muscle makes up 40% of the human body and has high energy and nutrient demands. However, until now scientists did not appreciate how skeletal muscle can similarly communicate with the brain through signalling factors called myokines.

“Until now, the brain has been the least-studied target of myokine activity,” said corresponding author Dr. Fabio Demontis, of the St. Jude Department of Developmental Neurobiology. “There are many myokines that act on other tissues, but their roles in signaling to the brain have been largely unexplored.” 

The molecular key to muscle-brain communication

To better understand how skeletal muscle communicates with the brain regarding feeding behaviour, the researchers looked at the myokine Dpp in fruit flies. Dpp is the fruit fly equivalent of the BMP2 and BMP4 signalling factors in humans. 

Scientists previously thought that Dpp only transmits signals at short distances. However, the researchers showed that fluorescently tagged Dpp travels long distances from the flight muscles of fruit flies to the brain. Furthermore, the researchers found that reducing Dpp levels promoted feeding and foraging behavior in fruit flies. Conversely, increasing Dpp levels reduced foraging and feeding. 

A link between Dpp, dopamine and feeding initiation

The researchers also found that muscle-derived Dpp regulates the levels of brain tyrosine hydroxylase, an enzyme key to the synthesis of the neurotransmitter dopamine. Among a number of other roles, dopamine has previously been linked to feeding behaviour. 

The researchers found that lowering Dpp levels in muscle led to higher levels of dopamine in the brain and increased feeding. Conversely flies with higher Dpp levels in muscle had lower levels of brain dopamine and were less likely to seek food. The researchers also found that modulation of dopamine synthesis in the brain is key to the regulation of feeding by muscle-derived Dpp.

“Dpp is doing more than anyone thought it was. Beyond feeding behavior, endocrine Dpp signaling could be regulating a number of other tissue and systemic functions, including disease processes that involve dopaminergic neurons, ” Demontis said. “And because Dpp has comparable proteins in humans, it may be relevant to feeding behavior and metabolic diseases in higher organisms.”

Article adapted from a St. Jude Children’s Research Hospital news release.

Publication: Muscle-derived Dpp regulates feeding initiation via endocrine modulation of brain dopamine biosynthesis. Robles-Murguia, M et al. Genes & Development (December 12, 2019): Click here to view.

Brain, Dopamine, Dpp, feeding behaviour, myokines

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