Mindzilla – CRISPR-Cas9

CRISPR-Cas9

New Gene-Delivery Vehicle could Make Gene Therapy for Muscle Diseases Safer and more Effective

September 10, 2021
Mindzilla

Cambridge, MA — Genetic muscle diseases lead to progressive muscle wasting and often early death, with few treatment options and no cure. Some gene therapies that use a harmless virus to deliver a...

Rheumatoid Arthritis Treated with Implanted Cells that Release Drug

September 7, 2021
Mindzilla

St. Louis, MO — With a goal of developing rheumatoid arthritis therapies with minimal side effects, researchers at Washington University School of Medicine in St. Louis have genetically engineered...

Scientists Harness Human Protein to Deliver Molecular Medicines to Cells

August 26, 2021
Mindzilla

Cambridge, MA — Researchers from MIT, the McGovern Institute for Brain Research at MIT, the Howard Hughes Medical Institute, and the Broad Institute of MIT and Harvard have developed a new way to deliver...

Accurate Evaluation of CRISPR Genome Editing

May 25, 2021
Mindzilla

Ramat Gan, Israel — CRISPR technology allows researchers to edit genomes by altering DNA sequences and by thus modifying gene function. Its many potential applications include correcting genetic defects,...

Gene Editing Expands to New Types of Immune Cells

May 12, 2021
Mindzilla

San Francisco, CA — In the decade since the advent of CRISPR-Cas9 gene editing, researchers have used the technology to delete or change genes in a growing number of cell types. Now, researchers at...

Scientists Set a Path for Field Trials of Gene Drive Organisms

December 18, 2020
Mindzilla

La Jolla, CA — The modern rise of gene drive research, accelerated by CRISPR-Cas9 gene editing technology, has led to transformational waves rippling across science. Gene drive organisms (GDOs),...

Researchers Identify Critical Molecules that Coronaviruses Hijack to Infect Human Cells

December 10, 2020
Mindzilla

San Francisco, CA — When a coronavirus–including SARS-CoV-2, which causes COVID-19–infects someone, it hijacks the person’s cells, co-opting their molecular machinery for its own...

Reproducing Pathophysiology of Polycystic Kidney Disease from Human iPS Cells

August 25, 2020
Mindzilla

Kumamoto, Japan — Joint research, led by Kumamoto University in Japan, has successfully reproduced the pathogenesis of autosomal dominant polycystic kidney disease (ADPKD) from human iPS cells in vitro....

Cell Diversity in the Embryo

August 4, 2020
Mindzilla

Munich, Germany — A research team at the Max Planck Institute for Molecular Genetics in Berlin has explored the role of factors in embryonic development that do not alter the sequence of DNA, but only...

New Understanding of CRISPR-Cas9 Tool could Improve Gene Editing

August 3, 2020
Mindzilla

Berkeley, CA — Within a mere eight years, CRISPR-Cas9 has become the go-to genome editor for both basic research and gene therapy. But CRISPR-Cas9 also has spawned other potentially powerful DNA manipulation...

Comparing 13 Different CRISPR-Cas9 DNA Scissors

June 26, 2020
Mindzilla

Daejeon, South Korea — CRISPR-Cas9 has become one of the most convenient and effective biotechnology tools used to cut specific DNA sequences. Starting from Streptococcus pyogenes Cas9 (SpCas9), a...

Study Shows Glaucoma Could Be Successfully Treated With Gene Therapy

April 22, 2020
Mindzilla

Bristol, UK — A new study led by the University of Bristol has shown a common eye condition, glaucoma, could be successfully treated with a single injection using gene therapy, which would improve...

Receptors for Immune Defence

March 17, 2020
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Munich, Germany — Adaptive immunity is a powerful defense mechanism in vertebrates. A finely tuned interplay of different cell types provides a pathogen-specific immune response to eliminate for example...

Strong Signals Show How Proteins Come and Go

March 10, 2020
Mindzilla

Houston, TX — A novel system to amplify gene expression signals could be a game-changer for scientists who study the regulatory processes in cells that are central to all life. The Rice University...

Huge Bacteria-Eating Viruses Close Gap Between Life and Non-Life

February 13, 2020
Mindzilla

Berkeley, CA — Scientists have discovered hundreds of unusually large, bacteria-killing viruses with capabilities normally associated with living organisms, blurring the line between living microbes...

New Tumour-Driving Mutations Discovered in Under-Explored Regions of Cancer Genome

January 20, 2020
Mindzilla

Toronto, ON — In an unprecedented pan-cancer analysis of whole genomes, researchers at the Ontario Institute for Cancer Research (OICR) have discovered new regions of non-coding DNA that, when altered,...

Disruption of Glycine Receptors to Study Embryonic Development and Brain Function

December 19, 2019
Mindzilla

Jupiter, FL — Glycine receptors are one of the most widely distributed inhibitory receptors in the central nervous system and have important roles in a variety of physiological processes. Researchers...

Researchers Unlock Potential to Use CRISPR to Alter Microbiome

October 7, 2019
Mindzilla

London, ON — Researchers at Western University have developed a new way to deliver the DNA-editing tool CRISPR-Cas9 into microorganisms in the lab, providing a way to efficiently launch a targeted...

New Crispr Class Expands Genetic Engineering Toolbox

September 25, 2019
Mindzilla

Durham, NC — Biomedical engineers at Duke University have used a previously unexplored CRISPR technology to accurately regulate and edit genomes in human cells. With this new approach, the researchers...

Novel Nanoparticles Deliver CRISPR Gene Editing Tools into Cell with Much Higher Efficiency

July 15, 2019
Mindzilla

Medford/Somerville, MA — A research collaboration between Tufts University and the Chinese Academy of Sciences has led to the development of a significantly improved delivery mechanism for the CRISPR/Cas9...

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