Mindzilla – CRISPR-Cas9

CRISPR-Cas9

Reproducing Pathophysiology of Polycystic Kidney Disease from Human iPS Cells

August 25, 2020
Mindzilla

Kumamoto, Japan — Joint research, led by Kumamoto University in Japan, has successfully reproduced the pathogenesis of autosomal dominant polycystic kidney disease (ADPKD) from human iPS cells in vitro....

Cell Diversity in the Embryo

August 4, 2020
Mindzilla

Munich, Germany — A research team at the Max Planck Institute for Molecular Genetics in Berlin has explored the role of factors in embryonic development that do not alter the sequence of DNA, but only...

New Understanding of CRISPR-Cas9 Tool could Improve Gene Editing

August 3, 2020
Mindzilla

Berkeley, CA — Within a mere eight years, CRISPR-Cas9 has become the go-to genome editor for both basic research and gene therapy. But CRISPR-Cas9 also has spawned other potentially powerful DNA manipulation...

Comparing 13 Different CRISPR-Cas9 DNA Scissors

June 26, 2020
Mindzilla

Daejeon, South Korea — CRISPR-Cas9 has become one of the most convenient and effective biotechnology tools used to cut specific DNA sequences. Starting from Streptococcus pyogenes Cas9 (SpCas9), a...

Study Shows Glaucoma Could Be Successfully Treated With Gene Therapy

April 22, 2020
Mindzilla

Bristol, UK — A new study led by the University of Bristol has shown a common eye condition, glaucoma, could be successfully treated with a single injection using gene therapy, which would improve...

Receptors for Immune Defence

March 17, 2020
Mindzilla

Munich, Germany — Adaptive immunity is a powerful defense mechanism in vertebrates. A finely tuned interplay of different cell types provides a pathogen-specific immune response to eliminate for example...

Strong Signals Show How Proteins Come and Go

March 10, 2020
Mindzilla

Houston, TX — A novel system to amplify gene expression signals could be a game-changer for scientists who study the regulatory processes in cells that are central to all life. The Rice University...

Huge Bacteria-Eating Viruses Close Gap Between Life and Non-Life

February 13, 2020
Mindzilla

Berkeley, CA — Scientists have discovered hundreds of unusually large, bacteria-killing viruses with capabilities normally associated with living organisms, blurring the line between living microbes...

New Tumour-Driving Mutations Discovered in Under-Explored Regions of Cancer Genome

January 20, 2020
Mindzilla

Toronto, ON — In an unprecedented pan-cancer analysis of whole genomes, researchers at the Ontario Institute for Cancer Research (OICR) have discovered new regions of non-coding DNA that, when altered,...

Disruption of Glycine Receptors to Study Embryonic Development and Brain Function

December 19, 2019
Mindzilla

Jupiter, FL — Glycine receptors are one of the most widely distributed inhibitory receptors in the central nervous system and have important roles in a variety of physiological processes. Researchers...

Researchers Unlock Potential to Use CRISPR to Alter Microbiome

October 7, 2019
Mindzilla

London, ON — Researchers at Western University have developed a new way to deliver the DNA-editing tool CRISPR-Cas9 into microorganisms in the lab, providing a way to efficiently launch a targeted...

New Crispr Class Expands Genetic Engineering Toolbox

September 25, 2019
Mindzilla

Durham, NC — Biomedical engineers at Duke University have used a previously unexplored CRISPR technology to accurately regulate and edit genomes in human cells. With this new approach, the researchers...

Novel Nanoparticles Deliver CRISPR Gene Editing Tools into Cell with Much Higher Efficiency

July 15, 2019
Mindzilla

Medford/Somerville, MA — A research collaboration between Tufts University and the Chinese Academy of Sciences has led to the development of a significantly improved delivery mechanism for the CRISPR/Cas9...

Linking Phenotypes to Genotypes: Newly Devised Gene-Editing Strategy

July 9, 2019
Mindzilla

The power and convenience of modern-day word-processing programs, like Microsoft Word, have revolutionized our daily tasks. Need to create a quick resume for a new job opportunity? Procrastinating...

Researchers Find Cause of Rare, Fatal Disease That Turns Babies’ Lips and Skin Blue

June 19, 2019
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Cincinnati, OH — Scientists used a gene editing method called CRISPR/Cas9 to generate mice that faithfully mimic a fatal respiratory disorder in newborn infants that turns their lips and skin blue....

New Genetic Weapons Challenge Sickle Cell Disease

June 3, 2019
Mindzilla

Houston, TX — Help for patients with sickle cell disease may soon come from gene editing to fix the mutation that causes the disease and boost the patient’s own protective fetal haemoglobin. New...

Risk and Unnaturalness Cannot Justify EU’s Strict Policy on GMO, Research Concludes

April 24, 2019
Mindzilla

Copenhagen, Denmark — The EU’s policy on GMO is extremely strict and prevents new GMO crops from being authorized. The policy is based on arguments about the risk and unnaturalness of GMO plants...

Researchers Optimize Gene Editing for SCD and Beta Thalassemia

March 29, 2019
Mindzilla

Boston, MA — Researchers at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center and the University of Massachusetts Medical School have developed a strategy to treat two of the most...

New Method to Boost CRISPR Efficiency Developed

March 6, 2019
Mindzilla

Dallas, TX — Scientists have developed a method to boost the efficiency of CRISPR gene editing in Duchenne muscular dystrophy (DMD), according to a study that could have implications for optimizing...

Scientists Sharpen Their Molecular Scissors and Expand Gene Editing Toolbox

February 25, 2019
Mindzilla

Winston-Salem, NC — Wake Forest Institute for Regenerative Medicine (WFIRM) scientists have figured out a better way to deliver a DNA editing tool to shorten the presence of the editor proteins in...

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