Mindzilla – Pluripotent Stem Cells

Pluripotent Stem Cells

Molecular Sleuthing Identifies and Corrects Major Flaws in Blood-Brain Barrier Model

February 9, 2021
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New York, NY — A type of cell derived from human stem cells that has been widely used for brain research and drug development may have been leading researchers astray for years, according to a study...

Scientists Regenerate Skin with Stem Cells to See How DNA Defects in Kids Cause Cancer

November 24, 2020
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Cincinnati, OH — Physicians and scientists at Cincinnati Children’s Hospital Medical Center used new stem cell technology to regenerate and study living patient-specific skin in the lab, giving...

New Insight into Mammalian Stem Cell Evolution

September 8, 2020
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Kyoto, Japan — The genes regulating pluripotent stem cells in mammals are surprisingly similar across 48 species, Kyoto University researchers report in the journal Genome Biology and Evolution. The...

Primitive Stem Cells Point to New Bone Grafts for Stubborn-To-Heal Fractures

June 17, 2020
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College Station, TX — Although most broken bones can be mended with a firm cast and a generous measure of tender loving care, more complicated fractures require treatments like bone grafting. Researchers...

Beta Cells From Stem cells

April 28, 2020
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Oberschleißheim, Germany — The loss of insulin-secreting beta cells by autoimmune destruction leads to type 1 diabetes. Clinical islet cell transplantation has the potential to cure diabetes, but donor...

Scientists Boost Gene-Editing Tools to New Heights in Human Stem Cells

February 3, 2020
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Phoenix, AZ — During the past decade, the gene editing tool CRISPR has transformed biology and opened up hopeful avenues to correct deadly inherited diseases. Last fall, scientists began the first...

Researchers Create Accurate Model of Organ Scarring Using Stem Cells in a Lab

December 11, 2019
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Los Angeles, CA — Every organ in the body is capable, to some extent, of repairing itself after an injury. As part of this process, scar tissue forms and then recedes to make room for normal tissue...

Protein that Governs Human Blood Stem Cell Self-Renewal, Researchers Identify

December 2, 2019
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Los Angeles, CA — UCLA scientists have discovered a link between a protein and the ability of human blood stem cells to self-renew. In a study published today in the journal Nature, the team reports...

Heart Attack Modelled with Human Stem Cells

November 7, 2019
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Okayama, Japan — Researchers at Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences developed a model of myocardial infarction using cardiomyocytes differentiated...

Ultrastructure of Focal Adhesion Scaffold Unveiled in Human Pluripotent Stem Cells

October 28, 2019
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Turku, Finland — Focal adhesions are known as signalling platforms broadcasting the information of the biochemical and physical qualities of the extracellular matrix into intracellular signalling cascades....

Simple Method to Improve Heart-Attack Repair Using Stem Cell-Derived Heart Muscle Cells

August 8, 2019
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Birmingham, AL — The heart cannot regenerate muscle tissue after a heart attack has killed part of the muscle wall. That dead tissue can strain surrounding muscle, leading to a lethal heart enlargement. Biomedical...

3D Miniature Livers Lead Way to Patient-Specific Drug Discovery

August 5, 2019
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Tokyo, Japan — The human liver is a vital organ involved in multiple functions. Because susceptibility to liver diseases is highly variable among patients, researchers from Tokyo Medical and Dental...

Stem Cell Scientists Clear Another Hurdle in Creating Transplant Arteries

May 9, 2019
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Madison, WI — Cardiovascular disease is a major cause of death worldwide, and treating it isn’t easy. The disease wreaks havoc on patients’ blood vessels and can require complex bypass...

Engineered ‘Suicide Genes’ Prevent Tumours in Stem Cell-Derived Beta Cells

February 19, 2019
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Miami, FL — Researchers have been advancing methods to generate insulin-producing beta cells from pluripotent stem cells (PSC) for the clinical treatment of type 1 diabetes (T1D). However, transplantation...

CRISPR Gene Editing Makes Stem Cells ‘Invisible’ to Immune System

February 18, 2019
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San Francisco, CA — UC San Francisco scientists have used the CRISPR-Cas9 gene-editing system to create the first pluripotent stem cells that are functionally “invisible” to the immune...

Team Grows Functioning Human Neural Networks in 3D from Stem Cells

October 19, 2018
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Medford/Somerville and Boston, MA — A team of Tufts University-led researchers has developed three-dimensional (3D) human tissue culture models for the central nervous system that mimic structural...

Researchers Create a Functional Salivary Gland Organoid

October 11, 2018
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Tokyo, Japan — A research group led by scientists from Showa University and the RIKEN Center for Biosystems Dynamics Research in Japan have, for the first time, succeeded in growing three-dimensional...

Researchers Develop New Method for Turning Skin Cells into Pluripotent Stem Cells

July 9, 2018
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Helsinki, Finland — Researchers have now for the first time succeeded in converting skin cells into pluripotent stem cells by activating the cell’s own genes.

New Insight into Embryonic Stem Cell Reprogramming

December 20, 2017
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Munich, Germany – A new study in Nature Genetics identifies a specific population of pluripotent embryonic stem cells that can reprogram to totipotent-like cells in culture.

Bioengineers Show Why Lab-Made Stem Cells Might Fail: Errors in DNA Folding

May 12, 2016
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Philadelphia, PA — Induced pluripotent stem cells hold promise for regenerative medicine because they can, in theory, turn into any type of tissue and because they are made from a patient’s own...

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