Mindzilla – Transcription factor

Regulator Proteins or Symphonies of Genes: Statistical Modelling Points Way Toward Unified Theory for DNA Folding

September 24, 2021
Mindzilla

Washington, DC — At more than 2 meters long, the human DNA molecule uses intricate folding patterns to fit into cells while locally unfolding to express genes. Such phenomena, however, are difficult...

Research Provides Evidence for How a Key Transcription Factor Manages Access to DNA

September 8, 2021
Mindzilla

Memphis, TN — CTCF is a transcription factor that has been a research target due to its role in regulating a critical oncogene called MYC. Scientists at St. Jude Children’s Research Hospital have found...

Hobit Turns Immune Cells into Killers

September 3, 2021
Mindzilla

Würzburg, Germany — When pathogens invade the human body, a rapid response is required. At the forefront of the immune response are special immune cells. They reside in various tissues such as the...

Machine Learning Algorithm Predicts How Genes are Regulated in Individual Cells

July 5, 2021
Mindzilla

Chicago, IL — A team of scientists at the University of Illinois Chicago has developed a software tool that can help researchers more efficiently identify the regulators of genes. The system leverages...

Researchers Use Deep Learning to Identify Gene Regulation at Single-Cell Level

January 15, 2021
Mindzilla

Irvine, CA — Scientists at the University of California, Irvine have developed a new deep-learning framework that predicts gene regulation at the single-cell level. Deep learning, a family of machine-learning...

Transcription Factors may Inadvertently Lock in DNA Mistakes

October 26, 2020
Mindzilla

Durham, DC — Transcription factor proteins are the light switches of the human genome. By binding to DNA, they help turn genes “on” or “off” and start the important process...

Researchers Discover How Cells Know Their Future and Forget Their Past

November 7, 2019
Mindzilla

Copenhagen, Denmark — Stem cells all share the potential of developing into any specific cell in the body. Many researchers are therefore trying to answer the fundamental questions of what determines...

Stress in Powerhouse of Cell

October 21, 2019
Mindzilla

Freiburg im Breisgau, Germany — Cells need powerhouses known as mitochondria to utilize the energy stored in our food. Most of the proteins required for this powerhouse function are encoded in the...

Finding of STEMIN for Feasible Reprogramming in Plants

July 11, 2019
Mindzilla

Nagoya, Japan — Stem cells self-renew and give rise to cells that are differentiated during development. These differentiated cells can change into stem cells under appropriate conditions in most plants,...

Study Reveals Structure of ‘Master Switch’ Controlling Cell Division

May 28, 2019
Mindzilla

Santa Cruz, CA — Unregulated cell division is a hallmark of cancer, and one of the key proteins involved in controlling cell division is called FoxM1. Abnormal activation of FoxM1 is a common feature...

‘Icebreaker’ Protein Opens Genome for T Cell Development, Researchers Find

February 21, 2018
Mindzilla

Philadelphia, PA — Almost all cells in the human body have identical DNA sequences, yet there are 200-plus cell types with different sizes, shapes, and chemical compositions.

Heat Shock Protein Appears to Switch On Schistosoma Invasion

September 12, 2016
Mindzilla

Cleveland, OH — A protein known for helping cells withstand stress may also act as a switch that triggers free-swimming Schistosoma larvae to begin penetrating the skin and transforming into the...

Genes That Promote Tumour Expansion Also Restrict Growth of Neighbouring Cells, Says Study

August 28, 2015
Kristina Popova

Barcelona, Spain — Scientists from the Institute for Research in Biomedicine (IRB Barcelona) found that the over-activation of two signalling pathways, which cause the excess growth of tumour cells...

Scientists Identify a Major Regulator of Mitochondrial Life Cycle

August 5, 2015
Kristina Popova

Cleveland, OH — Case Western Reserve University scientists have discovered that a protein called Kruppel-like Factor 4 (KLF4) controls mitochondria — the “power plants” in cells that...