Ubiquitin

Proteasome Phase Separation for Destruction

Tokyo, Japan — The proteasome is a major proteolytic machine that regulates cellular proteostasis through selective degradation of ubiquitylated proteins. As the maintenance of protein homeostasis...

Tracking Down False Parkers in Cancer Cells

Würzburg, Germany — Squamous cell carcinoma is a very unusual type of cancer. They occur in many tissues – for example in the lungs, esophagus, pancreas, throat and pharynx, and on the skin....

Molecule that can AUTAC Bad Proteins

Sendai, Japan — Tohoku University researchers have developed a strategy that could help cells get rid of disease-related debris. Further research could lead to treatments for neurodegenerative and...

Tipping the Scales

München, Germany — Human cells have a sophisticated regulatory system at their disposal: labelling proteins with the small molecule ubiquitin. In a first, a team from the Technical University of Munich...

Growing a Brain

Tokyo, Japan — Scientists identified two distinct control mechanisms in the developmental transition of undifferentiated stem cells into healthy brain cells. This fundamental research using mice may...

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