1 min readScientists Report Discovery of New Antibiotic That Kills Pathogens With No Detectable Resistance
Cambridge, MA — NovoBiotic Pharmaceuticals, LLC has announced the discovery and preclinical development of teixobactin, a compound belonging to a new class of antibiotics.
As reported in the journal Nature, the compound shows potent killing against a broad panel of bacterial pathogens including methicillin resistant Staphylococcus aureus (MRSA) and vancomycin resistant enterococci (VRE).
In addition, teixobactin showed favourable drug properties including excellent efficacy in three mouse models of infection (septicemia, skin and lung). In collaboration with the University of Bonn (Bonn, Germany) and Northeastern University (Boston, MA), teixobactin was shown to inhibit bacterial cell wall synthesis by binding to two cell wall components: lipid II and lipid III. The article reports that no resistant mutants of eitherm S. aureus or Mycobacterium tuberculosis could be generated.
“The need for new antibiotics is acute due to the global problem of pathogen drug resistance. Teixobactin’s dual mode of action and binding to non-peptidic regions suggest that resistance will be very difficult to develop” said Dr. Kim Lewis, co-founder of NovoBiotic. Teixobactin was discovered in a screen against the company’s extensive extract library generated from previously uncultured microbes. “The discovery of teixobactin is further evidence that our unique culturing technologies provide ready access to new chemistry from nature that can be screened for novel drug leads” said Dr. Dallas Hughes, President of NovoBiotic.
Article adapted from a NovoBiotic Pharmaceuticals news release.
Publication: A new antibiotic kills pathogens without detectable resistance. Losee L. Ling, Tanja Schneider, Aaron J. Peoples, Amy L. Spoering, Ina Engels, Brian P. Conlon, Anna Mueller, Till F. Schäberle, Dallas E. Hughes, Slava Epstein, Michael Jones, Linos Lazarides, Victoria A. Steadman, Douglas R. Cohen, Cintia R. Felix, K. Ashley Fetterman, William P. Millett, Anthony G. Nitti, Ashley M. Zullo, Chao Chen & Kim Lewis. Nature (2015): Click here to view.